Nature Made Digestive Ultra Strength Probiotic Review


After reviewing Jarrow’s Female Probiotic earlier, I decided to find another effective probiotic. I came across Nature Made Digestive Probiotics Ultra Strength, which has hundreds of positive reviews online and is considered among the best probiotics in the market.

In this Nature Made Digestive Probiotics Ultra Strength Review, I’ll discuss all the aspects of Nature Made Digestive Probiotics Ultra Strength. You will be able to make an informed decision after learning from my experience using this Probiotic.

What is Nature Made Digestive ProBiotic Ultra Strength? 


Nature Made Digestive Probiotics Ultra Strength is a probiotic which is also packed with 12 essential nutrients and multivitamins. This has been designed to support overall digestive health. Nature Made is a registered brand name of Pharmavite LLC, founded in 1971 by California pharmacist Barry Pressman. 

Pharmavite was acquired by Otsuka Pharmaceutical, a multibillion-dollar Japanese pharmaceutical giant in 1989. Pharmavite was one of the earliest players in the dietary probiotic supplement market. Its “Nature Made” range of nutritional probiotic supplements has been among the most successful and visible brands in the dietary supplement, probiotics, and vitamin niche for decades.

Nature Made has several popular products such as Nature Made Omega 3-6-9 supplement, Nature Made vitamin supplements, and Nature Made Melatonin. They also produce a range of other probiotics, such as Nature Made Fiber Gummies, Nature Made Acidophilus Probiotics Tablets, Nature Made Digestive Probiotics Ultra Strength Gummies, and Nature Made Digestive Probiotic + Energy B12 Gummies.

They also have Nature Made Digestive Probiotics Advanced Dual Action, which contains strains like Bifidobacterium Lactis. 

This Probiotics Review is not about Nature Made’s Dual Action product, but I will definitely test this out another time! It is also not related to a very similar sounding Probiotic called Nature's Bounty 10 Probiotic, which I have reviewed recently.

Nature Made Digestive Probiotics Ultra Strength is available at the company’s website (although it is out of stock here at the time of writing) and other online retailers like Amazon. The probiotic is currently being sold through Amazon Marketplace by independent retailers, for between $20 and $35 per box of 25 capsules.

Nature Made Digestive Probiotics Ultra Strength Strains / Ingredients

Nature Made Digestive Probiotics Ultra Strength contains the following ingredients:


Lactobacilli (Total of 27 Billion CFU):

  • Lactobacillus acidophilus LA-14
  • Lactobacillus plantarum LP-115
  • Lactobacillus paracasei LPC-37
  • Lactobacillus gasseri LG-36
  • Lactobacillus rhamnosus HN-001
  • Lactobacillus acidophilus NCFM
  • Lactobacillus casei LC-11

Bifidobacteria (Total of 27 Billion CFU):

  • Bifidobacterium lactis HN019
  • Bifidobacterium lactis B-420
  • Bifidobacterium lactis Bi-07
  • Bifidobacterium lactis B-04
  • Bifidobacterium bifidum/lactis BB-02

As you can see from the above list, this supplement focuses on probiotics rather than multivitamins, which is good news for people prioritizing a specific probiotic effect.

I was a bit disappointed to see it did not contain Bacillus Coagulans, a strain found in Nature Made Dual Action and Digestive Advantage probiotics gummy.

I was happy to see no glucose syrup (like in Dual Action Probiotic Energy B12), or starch since I am trying to cut that out of my diet. They are also Dairy-Free and Vegetarian, which I'm happy with, although they are not Gluten-Free or Vegan.

This probiotic supplement is not intended to diagnose, treat, or cure any diseases. Make sure you store it in a cool, dry place.

My Experience With Nature Made Digestive Probiotic Ultra Strength

I took this probiotic for 30 days and only noticed a minor reduction in IBS symptoms, and this also didn’t help with my yeast infection (1).

My indigestion was reduced but only slightly. In terms of regularity of bowel movements, again, I noticed only a slight positive effect.

This probiotic does have some effect, but I did not experience effects as significant as the manufacturer claimed. It certainly didn’t live up to the name “Ultra Strength”!

I didn’t change my regular diet during the days when I was taking this probiotic. That was because I already have a balanced and healthy diet, which doesn’t include red meat, fatty or fried foods, and junk food.

Nature Made Digestive Probiotic Ultra Strength Side Effects

Some users of this Probiotic have reported experiencing stomach pain, irregular bowel movements, bloating, diarrhea, and more after taking this probiotic (2). Thankfully, the only symptom I experienced was bloating, and only to a minor degree.

Because the Probiotic has a pretty high CFU count, the chances of side effects are increased. However, high CFU counts are also more likely to yield positive results, so it depends on the individual!

If you would like to learn more about CFU Counts and more, make sure to check out my Probiotic 101 Guide.

Nature Made Digestive Probiotic Ultra Strength Reviews

Nature Made Digestive Probiotics Ultra Strength has a wide range of customer responses on Amazon, although most are positive. 

Rachel G reported an amazingly positive effect, with bloating, stomach upset and bowel irregularity hugely reduced:


This anonymous user had less impressive results, with no noticeable change whatsoever, and issues with the bulkiness of the packaging:


Doc H had mostly positive effects and actually liked the packaging, although did not see why the price was so high compared to other probiotics:


Eagle Eyes also criticized the packaging, saying that the blister packs were wasteful. The effect was also unnoticeable:



  • Noticeable but slight positive effect on IBS symptoms
  • Arrived quickly from Amazon
  • High CFU count
  • No glucose or starchNo-questions-asked, 100% money-back guarantee


  • Relatively pricey compare to other similar Probiotics
  • Effects relatively minor for most users
  • Not gluten-free or vegan
  • Minor stomach bloating side-effect
  • Some users found the packaging wasteful and inefficient

Final Thoughts

Nature Made has a no-questions-asked, 100% money-back guarantee, which is a substantial positive for their brand. 

Any customer can request a refund directly from the company after answering a few questions about the Probiotic they bought. They can expect to get a full refund within a reasonable amount of time. 

Nature Made Digestive Probiotics Ultra Strength features a high CFU count; however, a higher CFU count isn't always better.

Nature Made is one of the most recognized and respected Probiotics supplement manufacturers in the industry and has been online for decades. But I also understand that even the best probiotics may not work for everyone, and the mixed reviews of this Probiotic show how differing reactions can be.

Probiotic Review Girl's Recommendation 

You might think I'm crazy...

Most probiotic supplements suck.

I know this from experience. Since launching Probiotic Review Girl in 2019, I bought and tested over 27 different probiotic brands.

I got burned so many times that I eventually did something "crazy"...

At the end of 2021, I launched my own probiotic supplement.

  • No Low or Super High CFU counts - We included a 40-Billion CFU count which gives the best results with minimal side effects
  • Probiotic Strains That Show Results - We hand picked every probiotic strain based on the quality of the medical studies available
  • Capsules Coated To Survive Stomach Acid - We made sure our capsules are coated in a Natural Marine Polysaccharide derived from brown seaweed to create a protective layer that survives stomach acid

No more stressing about low cfu counts and wether or not the probiotic capsule will survive my stomach acid. I finally have a probiotic supplement I KNOW will work the way I want it too.

I use it everyday after years of battling Irritable Bowel Syndrome (IBS), I now have my energy and social life back! 

The positive news? I have made my probiotic supplement available to Probiotic Review Girl readers and you can experience the gut health benefits yourself.

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