5 Lactobacillus Gasseri Health Benefits

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Lactobacillus Gasseri is a friendly gram-positive stain that under a microscope is rod-shaped and was said to be first discovered by a scientist called François Gasseri in around 1980.

For women, Lactobacillus Gasseri is said to be an important probiotic strain for the healthy functioning of the vaginal flora. It's easy enough to get more of this probiotic strain from fermented vegetable foods and some probiotic supplements.

This Lactobacillus Gasseri guide will go over the potential health benefits this strain may have but only according to real scientific studies & research up to the year 2022.

Irritable Bowel Syndrome

In 2017 the results of a clinical trial carried out by the Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan were shared. They were published in the peer-reviewed Journal of Applied Microbiology and looked at the effects of the Lactobacillus Gasseri strain CP2305 probiotic strain in 34 males and females diagnosed with IBS.


The participants consented to take 100 Billion CFU of the Lactobacillus Gasseri strain every single day for 1 month in the form of a fermented skimmed milk drink. The assess efficacy of the bacteria quality of life scores, IBS severity index scores, and blood/stool samples were taken at baseline to then again at the end of the 4 weeks.


With the results compared to a placebo group, the researchers were able to establish that IBS severity scores were lower showing that L. Gasseri bacteria helped with IBS. 16S-rDNA V4-V6 region-targeted pyrosequencing on stool samples showed that there were modulating effects on microbiota with Dorea, Enterococcus, and Dialister bacteria decreased proving that the bacteria affected the microbiome.

Weight Loss

This trial from the Milk Science Research Institute, Kawagoe, Saitama, Japan was published in 2014 in the peer-reviewed European Journal of Nutrition. It aimed that test the anti-obesity effects of Lactobacillus Gasseri SBT2055 (LG2055) through pro-inflammatory gene expression.


The study fed 6 mice a high-fat diet for 24 weeks alongside the Lactobacillus Gasseri bacteria with the hypothesis being that without the probiotic bacteria, the obesity effects would differ and this was proved true with the final results.


Triglyceride a type of fat found in blood was found to be lower in the liver, fat tissue mass was lower, and body weight was reduced. DNA microarray analysis showed that both CCL2 / CCR2 pro-inflammatory genes were inhibited and this could have positively contributed. The conclusion was that in mice, Lactobacillus Gasseri did appear to have an anti-obesity effect.

Inflammatory Bowel Disease

According to Medical News Today, chronic inflammation can potentially lead to hay fever, rheumatoid arthritis, periodontitis, and more. In 2015 it was estimated that 1.3% of the US population had Inflammatory Bowel Disease so and the symptoms of IBD can be painfully debilitating.


The 2007 study took 10 mice that had Colitis and their baseline markers were noted. They were then given Lactobacillus Gasseri steadily for 3-days. Colitis (IBD) is an inflammation of the inner lining in the colon. The results were published in The American Journal of Physiology-Gastrointestinal and Liver Physiology journal.


All 10 mice were checked up on and it was noted that L. Gasseri significantly reduced inflammation markers and the severity of their colitis. More specifically, neutrophils & macrophages which are thought to play a crucial role in inflammation response were reduced. It's worth noting that for some reason, male mice experienced stronger IBD benefits.

Vaginal Health

This 2015 study from BMC Infection Diseases included 40 Scandinavian female participants with Bacterial Vaginosis and Recurrent Vulvovaginal Candidiasis.

The study women participating in the study took EcoVag® along with anti-fungal medication or antibiotics.


EcoVag® which contains Lactobacillus Gasseri DSM 14869 and Lactobacillus rhamnosus DSM 14870 was taken for 5 days after antibiotic treatment. Women in the group who took fluconazole anti-fungal cream along with the probiotic cream were said to have a 100% cure rate within 6 months and 89% within 12 months but larger double-blind placebo-controlled studies were still needed to prove efficacy.

Nasal Allergies & Asthma

This 2016 preliminary human clinical trial gave 15 participants with perennial allergic rhinitis and high serum IgE levels 200ml of milk containing Lactobacillus Gasseri TMC0356 every day for 4-weeks. At around 28-days into the study, the high serum IgE levels were reduced and Rhinitis reactions to Japanese cedar pollen and mites were also down.


This second randomized placebo-controlled study gave 49 school children L. Gasseri every day for 2-months and 56 a placebo for the same amount of time. The children aged between 6-12 all had Asthma and Allergic Rhinitis and at the end of the study, they were examined.


Amazingly, clinical symptom scores for asthma and allergic rhinitis decreased in the probiotic-treated patients as compared to the controls. It's worth noting that to achieve these results the kids had to take a probiotic daily for 8 weeks but the results were quite clear.

Probiotics 101

Probiotics are friendly good bacteria that are essential for our Microbiome to flourish. The health benefits are well documented and vary between different strains.

Some of the best probiotic foods are fermented foods and include Kimchi, Sauerkraut, and Miso Paste. You can also buy probiotics in liquid form with dairy drinks like Kefir and Kombucha.

Some of the best probiotic strains are those of the Lactobacillus family but there are also Bifidobacterium strains and recently soil-based probiotic strains are starting to become more mainstream. FlowFlora is one probiotic strain you can buy that has both Bifidobacterium and Lactobacillus probiotic bacteria.

Probiotic bacteria take time to work and not everyone will experience the same results. Probiotics may also cause side effects like bloating, gas and diarrhea.

Closing Summary

Some of these studies look promising on the surface but keep in mind one was carried out on mice and not humans.

Others did not feature many participants and so the results may not be that accurate. The two allergic rhinitis studies look most promising.

The studies confirm that taking Lactobacillus Gasseri is not an overnight magic cure. It can take months to notice results and even then you may not experience any benefits.

You should always consult with a Doctor for any health problems and never use probiotics to self-treat any conditions. The content in this guide is not medical advice and I am not a Doctor.

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