5 Lactobacillus Casei Health Benefits


Lactobacillus Casei (L. Casei) operates most efficiently at a pH of 5.5 and is a type of good probiotic bacteria that may have benefits for gut health.

It is phylogenetically and phenotypically closely related to Lactobacillus Rhamnosus and Lactobacillus Paracasei but fundamentally is not the same.

In this guide I will be going over some of the potential health benefits of Lactobacillus Casei and Lactobacillus Casei Shirota based on the scientific studies that have been conducted. 


Lactobacillus Casei LBC80R is a strain of probiotic bacteria that has been shown to improve symptoms of irritable bowel syndrome in a 2018 randomized controlled trial.

113 subjects who were randomly assigned to take either a daily capsule containing a combination of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2, or a placebo, for 12 weeks.

The conclusion found that the active treatment improved several symptoms of IBS, including abdominal pain, distention, stool consistency and frequency, and quality of life in the patients taking the L. Casei strain.

The treatment was particularly effective in the female participants with IBS-D (diarrhea-predominant IBS. Adverse events were mild or moderate in most cases, with one severe case of cramping reported in the active treatment group but this eventually passed.


This clinical trial published in the Canadian Journal of Gastroenterology and Hepatology journal in 2003 found that drinking Yakult containing Lactobacillus Casei Shirota significantly improved gastrointestinal symptoms, in patients with chronic constipation.

Data showed 89% in L. Casei group and 56% of the placebo group experienced a positive effect on constipation. There were no reported adverse reactions and the researchers concluded the L. Casei strain may be an effective adjunctive therapy for chronic constipation but not a cure.

Lactose Intolerance

This study, published in the Nutrition in Clinical Practice journal in 2012, evaluated the effects of a probiotic combination containing Lactobacillus casei Shirota and Bifidobacterium breve Yakult on symptoms and breath hydrogen exhalation in lactose-intolerant patients.

The study included 27 participants who completed four hydrogen breath tests: a baseline condition, after taking lactase, at the end of a four-week period of probiotic supplementation, and a follow-up test three months after probiotic discontinuation.

The results showed that the probiotic combination significantly reduced symptom scores and breath hydrogen levels compared to the baseline condition. These effects appeared to persist for at least three months after probiotic consumption was suspended.

The researchers concluded that a four-week course of this probiotic combination may improve symptoms and decrease hydrogen production in lactose-intolerant patients.

Since the participants were able to digest milk better, L. Casei, could be useful for those who have to eat vegan yogurts even though they are not vegan.

Leaky Gut

This study, published in the PLOS One journal in 2011, investigated the effects of the Lactobacillus casei DN-114 001 on intestinal inflammation in a mouse model of inflammatory bowel disease but also ended up testing markers related to leaky gut syndrome.

L. Casei significantly reduced the severity of acute dextran sulfate sodium-induced colitis in the mice and the researchers evaluated intestinal permeability, tight junction protein expression, regulatory T cell numbers, microbiota composition, and cytokine production.

They found that L. Casei treatment strengthened the integrity of the intestinal barrier, increased the number of regulatory T cells in the mesenteric lymph nodes, decreased pro-inflammatory cytokine production, increased anti-inflammatory cytokine production in the gut, and changed the microbiota composition.


It's difficult to figure out what specific probiotic strain is Best For Diverticulitis. Some studies suggest Lactobacilli bacteria as a whole may be beneficial and Lactobacillus Reuteri in particular.

This research article, published in 2020, investigated the feasibility and potential benefits of a year-long probiotic intervention in primary care for patients with a history of uncomplicated acute diverticulitis. The study included 21 patients recruited from four general practices, who were asked to take a daily probiotic drink called Yakult.

The researchers compared the number of clinically diagnosed diverticulitis attacks in the six months before and after probiotic intervention, and also assessed gastrointestinal symptoms using validated questionnaires and diet diaries at various time points.

The results showed that among the subjects who demonstrated good adherence to the probiotic, two-thirds (14 out of 21) experienced an improvement in symptoms (p=0.025).

The rate of clinical presentation with diverticulitis episodes was also reduced by 50% during the study period compared to the 12 months before (7 vs 14 cases; p=0.021). The mean change in gastrointestinal symptom scores also improved significantly (p<0.001).

The researchers concluded that taking the daily probiotic was associated with a lower rate of clinical presentation with diverticulitis episodes and improvement in gastrointestinal symptoms, and that it is feasible to conduct a definitive trial in a primary care setting. However, they recommended including a method to validate the diagnosis of diverticulitis in future studies.

Side Effects & Warnings

Probiotics has difference effects on everyone based on their unique gut flora. Some people taking probiotics may experience side effects like Gas, Bloating, Diarrhea and more. If you experience any side effects you should consult with a Doctor asap and discontinue use.

Closing Statement

Never use Lactobacillus Casei as a replacement to any prescribed medication from your Doctor and also consult a Doctor for any medical queries. This guide is NOT medical advice and I am not a Doctor.

The Lactobacillus Casei and Shirota strain looks promising for a wide range of health issues but more in depth studies may be needed. The use of Lactose Intolerance looks to be the most promising and user reports are also positive.

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